Cell Death Protein Marks Vulnerable Nerve Cells in 2 SMA Mouse Models

MiceGroup

The elevated production of the cell-death-related protein c-Fos was closely linked to the death of motor neurons in two mouse models of spinal muscular atrophy (SMA), a study showed. Motor neurons are the muscle-controlling nerve cells that are lost in people with SMA. Although c-Fos didn’t directly cause the motor neurons’ death, and is therefore […]
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According to Spotify Wrapped, I’m Allergic to Silence

I listened to 78,978 minutes of music and podcasts in 2022. Thanks to the popular feature Spotify Wrapped, I and millions of users can look at a summary of our listening habits each year, for better or worse. Some may find my avid consumption of pop albums and Broadway show tunes healthy and therapeutic, while […]
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How ‘Andor’ Reminded Me of the Importance of Community Care

This year has been unprecedentedly good in terms of media. From season four of “Stranger Things” to the delightfully campy “Our Flag Means Death,” I’ve had no shortage of things to binge. But the highlight has undoubtedly been the renewed interest in “Star Wars.” It started with the six-episode limited series “Obi-Wan Kenobi,” starring Ewan […]
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Patients With Less Muscle Loss More Likely to Respond to Spinraza: Study

MRI adult

People with spinal muscular atrophy (SMA) types 2 or 3 who start treatment with Spinraza (nusinersen) and show less muscle damage on MRI scans are more likely to see motor function improvements, a new study reports. The finding “underscores the importance of early diagnosis and treatment to obtain the maximum effect” from treatment in SMA, […]
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Scoliosis Progression Detailed in Untreated SMA Type 2 Children

Severe scoliosis — an abnormal curvature of the spine — was significantly associated with older age and limited motor abilities in children with spinal muscular atrophy (SMA) type 2 who had not received disease-modifying therapies, a study showed. These findings establish characteristics of untreated scoliosis progression on SMA type 2 patients to which future studies […]
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